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The Sekyere South District formerly Afigya Sekyere District is located in the north eastern part of the Ashanti Region. Agona Ashanti which is the administrative capital, is located 37 kilometers from Kumasi, along the Kumasi - Mampong trunk road.

The District shares common borders with Ejura Sekyedumase Municipal to the north, Mampong Municipal and Sekyere East District to the east, Kwabre East District to the south and Offinso Municipal to the west.

The District has a total land area of 416.8 square kilometers representing about 1.7 percent of the total land size of the Region of 24,389 square kilometers. The District lies between latitude 6o 50’N and 70 10’N and Longitude 10 40’W and 10 25’ W.

The population of the District according to the 2010 Population and Housing Census stands at  94,009  with  44,691 male  49,318 female.