The Sissala East Municipal is located in the north-western part of Ghana in the Upper West Region. The Administrative district capital is Tumu. 

The Municipality is strategically positioned as it shares a 300 kilometre border with Burkina Faso to the North.

The Municipality shares boundaries to the east with Kassena Nankana East and Builsa districts, both of the Upper East Region while its extreme southeastern portion shares a boundary with Mamprugo-Moaduri District of the Northern Region, on the West the District shares boundaries with Sissala West and to the south Wa East.

The population of the District according to 2010 population and housing census stands at 56,528 with 27,503 males and 29,025 females.