The district is located in the south-western part of the Ashanti Region. It shares common boundary on its Western part with the Atwima District Its northern part can be found the Bosomtwe District, while a regional boundary separates it from Western Region on its Southern part. Manso Nkwanta is the capital. Amansie West was established by Legislative Instrument (L.I) 1403.
The population of the district according to the 2010 Population and Housing Census stands at 134,331 with 67,485 males and 69,790 females.