Sene East District was created out of the then Sene District (now known as Sene West) on 9th March, 2012 by a Legislative Instrument (LI) 2091 and inaugurated on 28th June, 2012 at Kajaji, the District Capital. It is about 295 kilometers from Sunyani, the Regional Capital of Brong Ahafo.
The Sene East District is located in the north-eastern corner of the Brong Ahafo Region of Ghana. It covers a vast land area of 4,392.4sq.km and shares boundaries with East Gonja District to the north, Krachi West to the East, Sene West to the West and Kwahu North to the south. The large land size could be seen as a potential area for agricultural development.The population of the district according to the 2010 populational and Housing Census stands at 60,511 with 31,910 males and 28,601 females.