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Nkwanta South District is one of the twenty five (25) Municipalities and Districts in the Volta Region of Ghana. The District is located in the northern - most part of the Region and was established by Legislative Instrument (L.I) 1892. It lies between latitudes 7 30° and 8 45° North and longitude 0 10° and 0 45° East. The district is bounded to the north by the Nkwanta North District, to the south by the Kadjebi District, to the East by the Republic of Togo and to the West by Krachi East District. Nkwanta South District was carved out of Kete Krachi District in 1989. The Administrative Capital of the District is Nkwanta.
The population of the District according to 2010 population and housing census stands at 117,878 with 58,482 males and 59,396 females.