Daffiama Bussie Issa District with its Administrative capital at Issa was carved from Nadowli and forms part of the new districts and municipalities created in the year 2012 and were inaugurated at their various locations simultaneously on the 28th June, 2012. It now forms part of the Eleven (11) Districts in the Upper West Region of Ghana. The President H.E. J.E.A Mills, by an Executive Instrument (E.I) created 46 new Districts. All the inaugurated and confirmed MMDAs established are operational with immediate effect hence bringing the total number of MMDAs to 216. The district was established by Legislative Instrument (L.I) 2100 and shares boundaries with Nadowli district to the west, to the South with Wa Municipal, to the East to Sissala West District and Wa East to the South East.
The population of the municipality according to 2010 population and housing census stands at 32,827 with 15,971 males and 16,856 females.