Ningo Prampam District with its capital Prampam was carved from Dangme West and forms part of the new districts and municipalities created in the year 2012 and were inaugurated at their various locations simultaneously on the 28th June, 2012. The President H.E. J.E.A Mills, by an Executive Instrument (E.I) created 46 new Districts. All the inaugurated and confirmed MMDAs established are operational with immediate effect hence bringing the total number of MMDAs to 216. The District was established by Legislative Instrument (L.I) 2035.The District forms part of the sixteen (16) Metropolis, municipalities and Districts in the Greater Accra Region. The District shares boundaries with Dangme West to the north, to the west with Kpone Katamanso District, to the east with Ada West District and to the South with the Gulf of Guinea.
The population of the district according to 2010 population and housing census stands at 70,923 with 33,514 males and 37,409 females.